Nanofibrous biologically soluble scaffolds as an effective drug delivery system

Authors

  • A. Kenzhebayeva Institute of combustion problems, Bogenbai Batyr Street, 172, Almaty, Kazakhstan; Satpayev University, Satpayev Street, 22, Almaty, Kazakhstan
  • B. Bakbolat Institute of combustion problems, Bogenbai Batyr Street, 172, Almaty, Kazakhstan
  • F. Sultanov Institute of combustion problems, Bogenbai Batyr Street, 172, Almaty, Kazakhstan; Al-Farabi Kazakh National University, 71 Al-Farabi ave., Almaty, Kazakhstan
  • Ch. Daulbaev Institute of combustion problems, Bogenbai Batyr Street, 172, Almaty, Kazakhstan; Nazarbayev University, 53, Kabanbay Batyr ave., Nur- Sultan, Kazakhstan
  • Z. Mansurov Institute of combustion problems, Bogenbai Batyr Street, 172, Almaty, Kazakhstan; Al-Farabi Kazakh National University, 71 Al-Farabi ave., Almaty, Kazakhstan
  • М. Алдашева S.D. Asfendiyarov, Kazakh National Medical University, Tole bi Street, 94, Almaty, Kazakhstan

DOI:

https://doi.org/10.18321/cpc444

Keywords:

electrospinning, hydroxyapatite, biologically soluble scaffolds, fibers, drugs.

Abstract

In this article, the synthesis of biocompatible fibrous scaffolds with antimicrobial properties based on polycaprolactone/hydroxyapatite/ amoxicillin and study of their surface morphology, antimicrobial effect, and drug release are discussed. Hydroxyapatite (1–2 μm, 97%) synthesized from biologically waste material (eggshell) was added to the composite scaffolds as a bone-replacement material. The scaffolds’ antimicrobial properties were evaluated against S.aureus and E.faecalis. The scaffolds possessed a sustained drug release from the scaffolds amounted to about 94% of the antibiotic’s total weight over a 4-week observation period. Agar diffusion confirmed the antimicrobial properties of the scaffolds against specific bacteria.

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Published

2021-10-12

How to Cite

Kenzhebayeva, A., Bakbolat, B., Sultanov, F., Daulbaev, C., Mansurov, Z., & Алдашева, М. (2021). Nanofibrous biologically soluble scaffolds as an effective drug delivery system. Combustion and Plasma Chemistry, 19(3), 209–217. https://doi.org/10.18321/cpc444

Issue

Vol. 19 No. 3 (2021): COMBUSTION AND PLASMA CHEMISTRY

Section

Статьи

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This work is licensed under a Creative Commons Attribution 4.0 International License.